Neuroprotective effects of soy isoflavones on scopolamine induced amnesia in mice by cong lu 1,2, yan wang 1, donghui wang 1, lijing zhang 1, jingwei lv 2, ning jiang 2, bei fan 1, xinmin liu 2 and fengzhong wang 1. Caine ed, weingartner h, ludlow cl, cudahy ea, wehry s. The doors a novel modification of this type of apparatus are used to diminish. Pharmacological evaluation of hibiscus abelmoschus against. The effects of a nootropic drug, oxiracetam 50100200 mgkg ip, and a potent antioxidant agent, ascorbic acid 62. Scopolamine is a prescription drug used in adults for prevention of nausea and vomiting. Scopolamine 3 mgkg ip given before an acquisition trial, reduced the retention of a onetrial passive avoidance step through response in mice. Effect of resveratrol on scopolamineinduced cognitive. The revival of scopolamine reversal for the assessment of. All the three doses demonstrated improved scopolamineinduced.
Animals were gavaged for 4 weeks with saline, sesame oil 0. Scopolamine has also been used clinically though less frequently than in past years as an adjunct to surgical or obstetric procedures to induce sedation and postprocedural amnesia. This study of scopolamineinduced memory deficits further defines those cognitive processes which are disrupted. Enduring amnesia induced by icv scopolamine is reversed by. When used by injection, effects begin after about 20 minutes and last for up to 8 hours. Ethanolic extract of orthosiphon stamineus improves memory in. Hyoscine, also known as scopolamine, is a medication used to treat motion sickness and postoperative nausea and vomiting. This study of scopolamineinduced memory deficits further defines those cognitive. Furthermore, scopolamine induced an increase in brain acetylcholinesterase and oxidative stress, responsible for amnesia, was significantly reduced by both the doses of lycopene. Pdf gongjindan enhances hippocampal memory in a mouse. Intrams injection of a subthreshold dose of nmda reduced scopolamine induced amnesia in the ms. International journal of pharmtech research coden usa.
It was given 30 min before retention trial in mwm, and 30 min before acquisition trial in epm. Acetylcholinesterase inhibitory activity and neuroprotection. Scopolamine injection significantly induced the lipid peroxidation in hippocampus p scopolamine induced amnesia has been proposed as a model for dementia where reduced cholinergic function is the suspected cause. Learn about side effects, drug interactions, dosages, warnings, and more. Scopolamineinduced amnesia has been proposed as a model for dementia where reduced cholinergic function is the suspected cause. Evaluation of anacyclus pyrethrum root extract on learning. Antiamnesic and neuroprotective effects of low dose of ramipril and losartan in scopolamine induced amnesia model of dementia deb, debasree and nayak, veena and bairy, kl and rao, mohandas kg and shetty, jeevan and hegde, mangala v and koshy, salini s 20 antiamnesic and neuroprotective effects of low dose of ramipril and losartan in. Antiamnesic activity of vitex negundo in scopolamine induced. May, 2019 amnesia persists for at least 120 minutes following iv administration. It is seen also with slow acting parenteral general anaesthetics. This model can be used to describe the therapeutic targets of memory impairment. Acetylcholine may be one of the nenotransmitters which mediates memory function, since the anticholinergic drug scopolamine produces. Antiamnesic and neuroprotective effects of low dose of.
Scopolamine, an anticholinergic drug, is reported to produce amnesia by interference of long term potentiation and has been used for discerning the efficacy of various antiamnesic drugs. Dec 23, 2015 scopolamine, dubbed the devils breath, is often referred to as the most dangerous drug in the world. Wistar rats 180200 g were trained on active avoidance task. Experimental evidence for the potential of lycopene in the. Studies of the antiamnesic effects and mechanisms of single and. Strength of scopolamineinduced amnesia as a function of time between training and testing. Therefore, the purpose of the present study was to examine the effects of soy iso. Mydriasis persists for up to 8 hours following im administration.
These results suggest that prunella vulgaris is suitable for treating mental impairments caused by cholinergic dysfunction. For animal experiments, scopolamineinduced amnesia icr mice were used to analyze the learning and memory functions of dc in comparison with the positive control donepezil. Neuroprotective effects of soy isoflavones on scopolamine. The animals were housed in standard laboratory conditions with pellet diet and water available ad libitum. The neurochemistry of memory remains to be determined. Scopolamineinduced amnesia models can be a useful endpoint to test. We report seven experiments in young adult mice which examine scopolamines effects on memory retention and whether its amnestic effects are specifically blocked by cholinergic agonists or cholinomimetics. Kshirsagar1 1sudhakarrao naik institute of pharmacy, pusad,m. These findings are in line with results derived from the docking simulations, and suggest that at least the succinamide of paminophenol could represent a novel candidate for the treatment of ad. A randomized, doubleblind, sponsor unblinded, placebo controlled, 5way, crossover study to evaluate the effects of single oral administrations of pf05212377 sam760, a 5ht6 antagonist, on scopolamine induced deficits in psychomotor and cognitive function in healthy young adults.
Qualitative analysis of scopolamine induced amnesia. Alzheimers disease model for amnesia studies charles river. Each animal received session of 15 trials with inter trial duration of 15 s for 5 days. In the present study we investigated the antiamnesic activity of vitex negundo in scopolamine induced amnesia in rats. Reversal of scopolamineinduced amnesia by the gabab receptor. Mainly prevalent in south america, the drug is used to commit the perfect crime while under the influence of scopolamine, someone could convince you to willingly withdraw and give away your life savings from your bank account, but. Moreover, it is well known that scopolamine is a muscarinic antagonist, which acts by increasing the phosphorylation of tau proteins leading to the formation of. Serum cholesterol and creactive protein crp levels were successfully reduced by lycopene. Antiamnesic activity of vitex negundo in scopolamine. Regular article strength of scopolamineinduced amnesia as a.
Qualitative analysis of scopolamineinduced amnesia. Despite this limitation, scopolamineinduced memory impairment, particularly when. Scopolamine induced amnesia is a very well recognized animal model of memory dysfunction, widely used to test potential drugs of antialzheimers properties 23. It is also sometimes used before surgery to decrease saliva. Scopolamine induced amnesia in rodent models has been widely used to understand the molecular, biochemical, behavioral changes, and to delineate therapeutic targets of memory impairment. Scopolamine is a wellknown cholinergic antagonist that causes amnesia in human and animal models. Scopolamine challenge study full text view clinicaltrials. Ethanolic extract of orthosiphon stamineus improves. Neuroprotective effects of soy isoflavones on scopolamineinduced amnesia in mice by cong lu 1,2, yan wang 1, donghui wang 1, lijing zhang 1, jingwei lv 2, ning jiang 2, bei fan 1, xinmin liu 2 and fengzhong wang 1. Moreover, intrams or ca1 injection of a subthreshold dose of nmda did not alter scopolamine response in the ca1 or ms respectively. Effect of a m1 allosteric modulator on scopolamineinduced.
Enduring effect of scopolamine on memory impairment has been shown by seifhosseini and colleague recently 24. Scopolamine crosses the placenta and is distributed into milk. This study of scopolamine induced memory deficits further defines those cognitive processes which are disrupted. Ymaze and novel object recognition apparatus served as the exteroceptive behavioural models, and scopolamine induced amnesia served as the interoceptive behavioural model. We studied the effects of cgp 35348, a centrally active blocker of gabab receptors, on scopolamineinduced amnesia for a passive avoidance response in the. To evaluated the longterm effect of scopolamine and sesame oil on spatial memory. A significant antiamnesic effect was also found with nootropic drugs such as piracetam and ucb l059. To study acquision, consolidation and recall stages of memory, aterials and methods.
The drugs which reverse the scopolamineinduced amnesia produce their effects by regulating the cholinergic system, mainly by modulating acetylcholine levels in the brain. A single administration of cholinergic agonists such as oxotremorine, bm5, or arecoline, antagonized this amnesic effect of scopolamine. Qualitative analysis of scopolamine induced amnesia caine, eric. May 14, 2015 scopolamine injection significantly induced the lipid peroxidation in hippocampus p scopolamine produces amnesia in man. Antiamnesic effects of a hydroethanolic extract of crinum. However, similar injection of nmda into ca1 did not alter scopolamine response when injected into ca1. The effects of ascorbic acid and oxiracetam on scopolamine. The paste of pa nuts was administered orally at three doses 150, 300 and 600 mgkg for 7 and 14 consecutive days to the respective groups of rats. Acetylcholine may be one of the neuotransmitters which mediates memory function, since the anticholinergic drug scopolamine produces amnesia in man. Effects of nootropic drugs in a scopolamineinduced. Amnesia may be therapeutic for medical treatment or for medical procedures, or it may be a sideeffect of a drug, such as alcohol, or certain medications for psychiatric disorders, such as benzodiazepines. To examine the antiamnesic effect of hsp72 overexpression, three groups of animals were subjected to scopolamine injection 30 min before the training trial or 30 min before the retention test 11.
Memory impairment induced by intracerebroventricular icv injection of scopolamine hydrochloride 10. Qualitative analysis of scopolamineinduced amnesia springerlink. Materials and methods swiss albino male mice weighing between 2530 g were procured from the central animal house, university college of medical sciences, delhi. Scopolamine induced amnesia is reversed by bacopa monniera. Amnesia of inhibitory avoidance by scopolamine is overcome by. We report seven experiments in young adult mice which examine scopolamine s effects on memory retention and whether its amnestic effects are specifically blocked by cholinergic agonists or cholinomimetics. Use of donepezil and ginkgo ketoester tablet on scopolamineinduced. Evaluation of anacyclus pyrethrum root extract on learning and memoryenhancing activityin albino wistar rats abhinav k, jogender m, madhusudana k, vegi gmn, yogendra kg, ramakrishna s. Effects of nootropic drugs in a scopolamineinduced amnesia. Scopolamineinduced amnesia can be prevented by heat shock. Scopolamine treatment produced strong amnesia in animals tested i and 3 days posttraining but normal retention in animals tested 7 and 10 days after learning. May 14, 2012 the drug, called scopolamine, also known as the devils breath, is derived from a particular type of tree common in colombia called the borrachero tree. Amnesia induced by scopolamine has been widely used to understand the biochemical and behavioral changes in rodents. Pdf in the present study we investigated the antiamnesic activity of vitex negundo in scopolamine induced amnesia in rats.
Amnesia was induced in mice by using scopolamine at a dose of 1 mgkg, i. Drugs az pill identifier supplements symptom checker diseases dictionary media. The light dark aversion test was selected and was carried out in aged mice. Aug 02, 2016 gongjindan enhances hippocampal memory in a mouse model of scopolamineinduced amnesia article pdf available in plos one 118. In modified passive avoidance, it was injected to animals 30 min before acquisition trial. Antiamnesic activity of vitex negundo in scopolamine induced amnesia in rats.
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